In their 2019 paper, “Novel molecular mechanisms for Prph2‐associated pattern dystrophy,” Chakraborty et al use the Phoenix MICRON™ IV retinal imaging platform to longitudinally study the effect of a very specific mutation affecting the Peripherin 2 protein. Peripherin 2 is a protein in rods and cones which, if mutated, can lead to retinitis pigmentosa, cone-rod
Microglia respond to neurological injury but the precise way they help to clear and remodel the injuries is not known. In their paper, “Optic nerve as a source of activated retinal microglia post-injury,” Heuss et al investigate a population of microglia-like cells that proliferate in the retina after an optic nerve injury. They identify GFPhi myeloid
In a recent well written, compelling article published in Nature Communications, “Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion,” Avrutsky et al show that caspase-9 inhibition is a promising treatment for retinal vein occlusion. Retinal vein occlusion models hypoxic-ischemic neurovascular damage and is the second leading cause of blindness in working-age adults.
In the July edition of Nanomedicine journal, Chemla et al demonstrate a fascinating and novel way to label and track individual photoreceptor precursor cells migrating within the retina with fluorescence and gold nanoparticle tagging using the Phoenix MICRON and OCT. Many retinal diseases such as age-related macular degeneration and retinitis pigmentosa are characterized by photoreceptor
Dr. Rafael Ufret-Vincenty’s lab at University of Texas Southwestern Medical Center has developed a novel model for light damage using the Micron IV rodent retinal imaging camera. This quick and consistent light damage model leads to fundus abnormalities and retinal thinning as measured by the Micron image-guided OCT and semi-automated layer analysis tool, Insight. In two elegant articles, the researchers provided proof of concept in pigmented mice, which are a better model for human eye light damage than overly sensitive albino mice, which demonstrated bleached fundus and outer retinal layer thinning.
Using the Phoenix retinal imaging and functional measurement to study retinal ganglion cell survival during chronic (glaucoma) and acute (optic nerve crush) injury
Liu et al studied the survival and dysfunction of retinal ganglion cells (RGC) during chronic (glaucoma) and acute (optic nerve crush) injury in a series of comprehensive and elegant articles published from 2015 to 2017. The researchers used the Phoenix ERG and Micron IV provide a complete picture of RGC disruption.