2020

A year-long longitudinal pattern dystrophy fundus study with the Phoenix MICRON™ IV imaging platform

In their 2019 paper, “Novel molecular mechanisms for Prph2‐associated pattern dystrophy,” Chakraborty et al use the Phoenix MICRON™ IV retinal imaging platform to longitudinally study the effect of a very specific mutation affecting the Peripherin 2 protein. Peripherin 2 is a protein in rods and cones which, if mutated, can lead to retinitis pigmentosa, cone-rod

2020

RPE mutations lead to retinal hypopigmentation, vasculature changes, and decreased function

In their paper, “The microphthalmia-associated transcription factor (Mitf) gene and its role in regulating eye function,” García-Llorca et al use the Phoenix MICRON™ IV to examine the outer eye appearance, retinal pigmentation, and retinal vasculature through fluorescein angiography to study several different mouse mutants. Combined with electroretinography and histology, the fundus images tell a story

2019

Phoenix MICRON FA reveals more leakage in iron-overload model of diabetic retinopathy

Diabetic retinopathy is a crippling complication of diabetes that can lead to loss of vision, characterized by retinal inflammation, neurodegeneration, and disorganized microvascularization . Oxidative stress is crucial to the development of diabetic retinopathy. Iron is an essential micronutrient but, in excess, can become a highly damaging oxidative species. Excessive iron has been implicated in Parkinson’s

2019

Phoenix MICRON™ OCT tracks individual stem cells in the rat retina

In the July edition of Nanomedicine journal, Chemla et al demonstrate a fascinating and novel way to label and track individual photoreceptor precursor cells migrating within the retina with fluorescence and gold nanoparticle tagging using the Phoenix MICRON and OCT. Many retinal diseases such as age-related macular degeneration and retinitis pigmentosa are characterized by photoreceptor

2019

Using the Phoenix MICRON™ IV to examine a potential treatment for disrupted retinal vasculature

Many eye diseases, including age-related macular degeneration, diabetic macular edema, cancer growth, and uveitis, involve disrupted blood vessel growth and leakage. Curing the leakage and growth helps modulate and treat the underlying disease. The Phoenix MICRON™ IV fundus camera allows for clear visualization of the rodent vasculature in bright field and with fluorescein angiography. Mirando

2019

Developing a unique, novel dry AMD model with the Phoenix MICRON laser injector

The most common cause of blindness in developed societies, age-related macular degeneration (AMD) robs the victim of the crucially important focused macular vision. While still devastating, wet AMD has a robust mouse model and the treatment option of anti-vascular endothelial growth factor (VEGF) subretinal injections. The Phoenix MICRON laser allows precise delivery of 532 nm

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