2020

Targeting VEGF164 in Müller cells may be useful to treat retinopathy of prematurity

In Nature’s Scientific Reports, Becker et al use the Phoenix MICRON IV, OCT, and focal ERG to assess the therapeutic value of knocking down a splice variant of VEGF in Müller cells in a model of Retinopathy of Prematurity (ROP). ROP is characterized by delayed vascularization of the retina after disrupted oxygen levels, followed by

2020

Imaging unanesthetized mice with the Phoenix MICRON™ OCT provides consistent retinal degeneration measurements

In the recently published review, “Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss,” researchers from The Jackson Laboratory in Bar Harbor, Maine and Mahidol University in Bangkok, Thailand performed an extensive literature search to find mouse models of single-gene mutations leading to photoreceptor loss and retinal degeneration. Using the Phoenix MICRON III and

2020

Retina as window to the brain: Stunning Phoenix MICRON™ fluorescein angiography images of brain and retinal vasculature

Novel comparison of retina and brain vasculature leads to stunning Phoenix MICRON images of fluorescent brain blood vessels The Phoenix MICRON imaging platform produces stunning images of fluorescent retinal vasculature through fluorescein angiography but for the first time, researchers have also captured beautiful images of cortical brain vasculature. Hui et al, in their well-written and

2020

Measuring adeno-associated virus improvements with Phoenix MICRON™ fluorescent imaging and Phoenix MICRON™ Ganzfeld ERG

A team of researchers at the Indian Institutes of Technology have published three detailed articles examining how to improve adeno-associated viruses (AAV). Maurya, S, Mary, B, Jayandharan, GR et al -approach the improvement of the viruses in a stunningly detailed gene-to-cell-to-whole-mouse model, narrowing down a multitude of options and producing impressive fluorescent fundus images and

2019

Phoenix MICRON FA reveals more leakage in iron-overload model of diabetic retinopathy

Diabetic retinopathy is a crippling complication of diabetes that can lead to loss of vision, characterized by retinal inflammation, neurodegeneration, and disorganized microvascularization . Oxidative stress is crucial to the development of diabetic retinopathy. Iron is an essential micronutrient but, in excess, can become a highly damaging oxidative species. Excessive iron has been implicated in Parkinson’s

2019

Phoenix MICRON™ OCT tracks individual stem cells in the rat retina

In the July edition of Nanomedicine journal, Chemla et al demonstrate a fascinating and novel way to label and track individual photoreceptor precursor cells migrating within the retina with fluorescence and gold nanoparticle tagging using the Phoenix MICRON and OCT. Many retinal diseases such as age-related macular degeneration and retinitis pigmentosa are characterized by photoreceptor

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