Microglia respond to neurological injury but the precise way they help to clear and remodel the injuries is not known. In their paper, “Optic nerve as a source of activated retinal microglia post-injury,” Heuss et al investigate a population of microglia-like cells that proliferate in the retina after an optic nerve injury. They identify GFPhi myeloid
In a recent well written, compelling article published in Nature Communications, “Endothelial activation of caspase-9 promotes neurovascular injury in retinal vein occlusion,” Avrutsky et al show that caspase-9 inhibition is a promising treatment for retinal vein occlusion. Retinal vein occlusion models hypoxic-ischemic neurovascular damage and is the second leading cause of blindness in working-age adults.
Novel comparison of retina and brain vasculature leads to stunning Phoenix MICRON images of fluorescent brain blood vessels The Phoenix MICRON imaging platform produces stunning images of fluorescent retinal vasculature through fluorescein angiography but for the first time, researchers have also captured beautiful images of cortical brain vasculature. Hui et al, in their well-written and
A team of researchers at the Indian Institutes of Technology have published three detailed articles examining how to improve adeno-associated viruses (AAV). Maurya, S, Mary, B, Jayandharan, GR et al -approach the improvement of the viruses in a stunningly detailed gene-to-cell-to-whole-mouse model, narrowing down a multitude of options and producing impressive fluorescent fundus images and
Diabetic retinopathy is a crippling complication of diabetes that can lead to loss of vision, characterized by retinal inflammation, neurodegeneration, and disorganized microvascularization . Oxidative stress is crucial to the development of diabetic retinopathy. Iron is an essential micronutrient but, in excess, can become a highly damaging oxidative species. Excessive iron has been implicated in Parkinson’s